CCL11, C-C motif chemokine ligand 11, 6356

N. diseases: 250; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 AlteredExpression group BEFREE Although it has recently been demonstrated that epithelial cells express eotaxin, both in vivo and in vitro, there are few data concerning the expression in viral infection. 11422151 2001
CUI: C0947751
Disease: Vascular inflammations
Vascular inflammations 		0.010 AlteredExpression phenotype BEFREE Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. 11056090 2000
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.010 Biomarker disease BEFREE In 27 older adults (mean age: 68 ± 5.2 years) with major depressive disorder, we performed a whole brain (voxel-wise) analysis testing whether/where gray matter density statistically mediates the cross-sectional association of eotaxin and set-shifting performance. 27645461 2017
CUI: C0941057
Disease: Ulcerative colitis, quiescent
Ulcerative colitis, quiescent 		0.010 AlteredExpression disease BEFREE Colon eotaxin-1 levels were significantly increased in active but not in quiescent ulcerative colitis and Crohn's disease patients compared to healthy controls. 26874691 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE In inflammatory bowel diseases (IBDs), particularly ulcerative colitis, intestinal macrophages (MΦs), eosinophils, and the eosinophil-selective chemokine CCL11, have been associated with disease pathogenesis. 23562811 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Serum CCL11/eotaxin-1 was increased significantly in UC (306 ± 87 pg/ml) and less so in CD (257 ± 43 pg/ml), whereas CCL24/eotaxin-2, and CCL26/eotaxin-3 were increased only in UC. 21077277 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis. 23904440 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Eotaxin, determined individually or in a panel with IFN<i>γ</i> and hsCRP, showed fair accuracy in differentiating CD from UC. 30147719 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 AlteredExpression disease BEFREE Our results did not show any statistically significant change in serum eotaxin-1 levels among ulcerative colitis, Crohn's disease and healthy controls. 26874691 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Eotaxin messenger RNA accumulates markedly in the lesions of patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease), but not in the lesions of patients with diverticulitis. 8597956 1996
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease LHGDN In situ and immunofluorescence analysis-identified eotaxin-1 expression was restricted to intestinal F4/80(+)CD11b(+) macrophages in DSS-induced epithelial injury and to CD68(+) intestinal macrophages and the basolateral compartment of intestinal epithelial cells in pediatric UC. 18981162 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 Biomarker disease BEFREE Two genes in UC (CCL11 and MMP10) and two in CD (C4BPB and IL1RN) showed an upregulation trend in both noninflamed and inflamed mucosa compared to controls. 30417021 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.090 AlteredExpression disease BEFREE Eotaxin-3 mRNA expression was elevated significantly in the active lesions of ulcerative colitis (UC) patients. 23607908 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Furthermore, inactivation of the ERK pathway suppressed the eotaxin‑1-promoted invasion and migration, and decreased MMP-3 expression in the prostate cancer cells. 24604010 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 AlteredExpression phenotype BEFREE We then demonstrated in vitro that both CCL11 and its receptor, CCR3, were overexpressed and promoted the proliferation, migration and invasion of cancer cells. 27119233 2016
CUI: C1857276
Disease: Trichohepatoenteric Syndrome
Trichohepatoenteric Syndrome 		0.010 Biomarker disease BEFREE Patients and their parents have high plasma levels of the chemokines MCP-1 and eotaxin, providing evidence for both a genetic and an immunological/inflammatory origin for the syndrome (Zhang et al., 2008, Exp.Biol.Med.233: 1171-1180). 20041150 2009
CUI: C0040580
Disease: Tracheal Diseases
Tracheal Diseases 		0.010 Biomarker group BEFREE Amelioration of eosinophil infiltration near the trachea was associated with reduced eotaxin and vascular cell adhesion molecule-1 (VCAM-1) levels. 26807923 2016
CUI: C3272265
Disease: Three Vessel Coronary Disease
Three Vessel Coronary Disease 		0.010 GeneticVariation disease BEFREE Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. 26491210 2015
CUI: C1861303
Disease: SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder)
SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder) 		0.010 AlteredExpression disease BEFREE Notable was allergen-specific α7 modulation of Ccl11 and Ccl24 (eotaxins) expression, which was enhanced in HDM but suppressed in OVA EOS. 29975102 2018
CUI: C1318020
Disease: Stromal keratitis
Stromal keratitis 		0.010 Biomarker disease BEFREE Such mice demonstrate that eotaxin enhances the magnitude of the early (but not late) eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis. 9034156 1997
CUI: C3178801
Disease: Stroke, Lacunar
Stroke, Lacunar 		0.010 Biomarker disease BEFREE CONCLUSIONS This study demonstrates that the CCL11 gene could play an important role in the pathogenesis of lacunar stroke and LAA stroke in the Han population of China. 28873081 2017
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.010 Biomarker phenotype BEFREE Administration of the DPP4 inhibitor sitagliptin resulted in higher concentrations of the chemokine CCL11 and increased migration of eosinophils into solid tumors. 30778250 2019
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.010 GeneticVariation phenotype BEFREE Carriers with the mutant allele of rs1129844, a functional single nucleotide polymorphism (Ala23Thr) in the CCL11 gene, showed a higher plasma level of Aß42, ratio of Aß42/Aß40, and insomnia side effect symptom score than the GG genotype carriers among MMT responders with morphine-negative urine results. 29222992 2018
CUI: C0037284
Disease: Skin lesion
Skin lesion 		0.010 Biomarker group BEFREE Within the subepithelium acute and chronic skin lesions exhibited a significant increase in the numbers of eotaxin and MCP-4 mRNA-positive cells compared with uninvolved skin (P <.01), whereas the numbers of eotaxin and MCP-4 mRNA-positive cells were significantly higher in chronic AD compared with acute AD skin lesions (P <.005, P <.001, respectively). 10808183 2000
CUI: C0037199
Disease: Sinusitis
Sinusitis 		0.010 AlteredExpression disease BEFREE Compared with normal controls, the numbers of cells expressing eotaxin mRNA and protein were significantly increased in both allergic and nonallergic sinusitis (P < 0.001). 9409555 1997